This is in contrast to neuronal antibodies that have already been shown to be directly involved in the pathogenesis of ataxia (e.g. dipeptidyl-peptidase-like-6 [DPPX], metabotropic glutamate receptor 1 [mGluR1], glutamic acid decarboxylase [GAD]-65). The gene discussed is DPP6; the disease is cerebellar ataxia.