ANP and BNP exhibit diuretic, natriuretic, vasorelaxant, antiproliferative, antiinflammatory, and antihypertrophic effects that are directed toward the reducing and controlling of body fluid volume, blood pressure (BP) and cardiovascular diseases (CVDs) (McGrath et al., 2005; Ellmers et al., 2007; Wang T.J. et al., 2007; Pandey, 2011; Volpe et al., 2014; Cannone et al., 2019). This evidence concerns the gene NPPB and cardiovascular disorder.