NPR1 and cardiac hypertrophy: Mice lacking NPRA develop cardiac hypertrophy and fibrosis, independent of BP (Oliver et al., 1997; Nakanishi et al., 2005; Vellaichamy et al., 2005a, 2007, 2014; Ellmers et al., 2007; Scott et al., 2009; Zhao et al., 2013).