NFKB1 and cardiac hypertrophy: Previous studies indicated that the activation of NF-κB and proinflammatory cytokines serve as a causal event in the development of cardiac hypertrophy and fibrosis (Frantz et al., 2003; Purcell and Molkentin, 2003; Li et al., 2004; Vellaichamy et al., 2005a; Subramanian et al., 2016).