The high plasma levels of ANP and BNP tend to predict cardiac events and CHF but BNP levels rise 10−25-fold higher than the fold increases in ANP concentrations (Mukoyama et al., 1991; Tsutamoto et al., 1993; Chen and Burnett, 1999; Felker et al., 2006; Reinhart et al., 2006; Pandey, 2019; Volpe et al., 2019a). This evidence concerns the gene NPPB and congestive heart failure.