NPPA and cardiovascular disorder: ANP and BNP exhibit diuretic, natriuretic, vasorelaxant, antiproliferative, antiinflammatory, and antihypertrophic effects that are directed toward the reducing and controlling of body fluid volume, blood pressure (BP) and cardiovascular diseases (CVDs) (McGrath et al., 2005; Ellmers et al., 2007; Wang T.J. et al., 2007; Pandey, 2011; Volpe et al., 2014; Cannone et al., 2019).