Several studies have demonstrated a link of ANP (NPPA), BNP (NPPB), and NPRA (NPR1) polymorphisms with hypertension and CVDs in humans (Rubattu et al., 2006; Webber and Marder, 2008; Xue et al., 2008; Newton-Cheh et al., 2009; Vandenwijngaert et al., 2019). This evidence concerns the gene NPR1 and hypertensive disorder.