MTOR and hypertrophy: Investigations have established dynamic phenomenon for AT1 R dependent transactivation of growth factor receptor-like EGF receptor (EGFR), followed by subsequent activation of Akt/p70S6, mechanistic target of rapamycin (mTOR), and Ras/ERK signaling resulting in cardiac hypertrophy and fibrosis (Eguchi et al., 1999; Eguchi et al., 2001; Ohtsu et al., 2006).