AT2 R may also counter-regulate functions mediated via AT1 R. However, the signaling mechanisms of AT2 R are still speculative compared with those of AT1 R. Moreover, most of the classic cardiovascular effects of Ang II are conveyed by AT1 R, including, vasoconstriction, hyperplasia, sodium retention, vascular cell hypertrophy, myocardial fibrosis, arterial wall thickening, aggravation of inflammatory responses, and stimulation of ROS. Here, AGTR1 is linked to Myocardial fibrosis.