Neuron-derived orphan receptor-1 (NOR-1) transgenesis upregulates key genes involved in cardiac hypertrophy (Myh7, encoding for β-myosin heavy chain (β-MHC)) and fibrosis (Loxl2, encoding for the ECM modifying enzyme, Loxl2) in Ang II-induced cardiomyocytes (Cañes et al., 2020). This evidence concerns the gene LOXL2 and hypertrophy.