Since the discovery of Ang II, it has been characterized to be involved in various cellular activities such as proliferation, contractility, apoptosis, dysfunctions, remodeling, etc. Dysregulated Ang II signaling is considered to induce various cardiovascular diseases involving hypertension, inflammation, myocardial infarction, atherosclerosis, fibrillation, ventricular dystrophies, etc. While many ARBs are available commercially, the statistics indicate the need to look for novel mechanisms of Ang II causing cardiovascular diseases independently, which would provide a therapeutic target. Here, AGT is linked to atherosclerosis.