TLR4 and Hypertension: These findings were consistent with reports by Li et al. (2016) and Yu et al., 2015 that showed Ang II increases hypertension and hypothalamic infiltration via TLR4/MyD88/NF-κB signaling pathway and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the PVN in hypertensive rats (Yu et al., 2015; Li et al., 2016).