VCAM1 and endothelial dysfunction: Insufficient adenosine formation linked to deficits in CD73 enzymatic activity has been associated with age-dependent endothelial dysfunction and NO production deficits in mice (Mierzejewska et al., 2019), which may strengthen the production of the pro-inflammatory cytokine, IL-6, and endothelial adhesion molecules, like intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 (VCAM-1) (Mierzejewska et al., 2019).