On the other hand, blockage of the A2BAR with MRS1754 significantly decreased albuminuria and improved the renal function in streptozotocin-induced diabetic mice; the antagonism of overexpressed A2BAR normalized VEGF-A upregulation in these animals while enhancing NO production and decreasing the occurrence of glomerulosclerosis lesions (Table 2) (Patel and Thaker, 2014). This evidence concerns the gene VEGFA and glomerulosclerosis.