ADA and Insulin resistance: ADA acting on RNA 1-deficient heterozygous mice fed with a high-fat diet (HFD) for 12 weeks exhibited a lean phenotype compared to wild-type controls which became obese within the same time period; the lean phenotype was associated with less severe dyslipidaemia and insulin resistance parameters, along with decreased food intake, decreased gastric ghrelin expression, and attenuated reduction of serum peptide YY levels (Cui et al., 2021).