METTL3 and Alzheimer disease: Ma et al. (2018) found that the nuclear output of hypermethylated RNAs increased in the cerebellum of ALKBH5 deficient mice exposed to hypobaric hypoxia. The expression of the m6A writers METTL3, METTL14, and WTAP and the erasers ALKBH5 and FTO in mouse cerebellum were spatiotemporal specific. Interestingly, the expression of METTL3 increases and the FTO decreases in AD mice. This suggests that the differentially expressed m6A methylated RNAs may play important roles in AD pathogenesis (Huang et al., 2020a; Han et al., 2020).