Therefore, the METTL3/YTHDF2/PTEN axis plays an important role in the proliferation of PASMCs induced by hypoxia, which provides a new diagnostic and therapeutic target for the treatment of hypoxic PAH (Liu et al., 2017; Xing et al., 2019; Qin et al., 2021). Here, METTL3 is linked to pulmonary arterial hypertension.