The present study revealed that Deh enhanced the viability of cardiomyocytes in an Escherichia coli (E. coli)- or LPS-induced sepsis model, inhibited cell apoptosis, reduced IL-1β and TNFα levels, and upregulated the expressions of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in the plasma and culture medium. The gene discussed is SOD1; the disease is Sepsis.