BDNF and nervous system disorder: As above described, our present study demonstrated the inconsistent time-dependent effects of TMP on the epileptogenesis and chronic pain, compared to its effects on the psychiatric comorbidity, and elucidated a novel function for clinic TMP administration that early application of TMP might enhance hippocampal BDNF/ERK signaling to alleviate anxiety and depressive comorbidities in neurological diseases.