BDNF and epilepsy: In addition, a variety of epilepsy models have shown that seizures induce transient increase of BDNF in neurons, in spite of the effects of BDNF in the development of behavioral seizures with different kindling paradigms are controversial, according to the previous findings (Reibel et al., 2000a; Reibel et al., 2000b; Scharfman et al., 2002).