Impaired BDNF/ERK signaling has a crucial role in the development of epileptogenesis (Xu et al., 2004), as well as the neuropsychiatric comorbidities (Wang and Mao 2019), so we further determined if TMP (50 mg/kg, i.p., D1-D35) improved anxiety and depressive like behaviors by increasing hippocampal BDNF/ERK signaling by Western blotting. Here, BDNF is linked to Anxiety.