LBP possibly inhibit the expression of genes such as COL-1 and α-SMA in inflamed lung tissues, weaken the excessive proliferatsion of fibroblasts and prevent their differentiation into myofibroblasts, thereby reducing the content of HYP in lung tissues to inhibit the development of PF in C57BL/6 mice (Liu et al., 2016b). This evidence concerns the gene ACTA1 and pemphigus foliaceus.