The overproduction of TGF-β1 is always closely related to PF, and TGF-β1 plays a key role in inducing EMT (Walton et al., 2017), nuclear factor-kB (NF-kB) regulates the expression of a variety of cytokines and inflammatory mediators, by inhibiting the expression of TGF-β1/NF-kB to block related signal pathways and prevent inflammation and reduce liver fibrosis (Li et al., 2018a). This evidence concerns the gene NFKB1 and pemphigus foliaceus.