MS80 inhibits BLM-induced PF in vivo, antagonizes TGF-β1-induced human embryo pulmonary fibroblast (HEPF) cells proliferation in vitro, prevents COL deposition and MMP activity, and inactivates ERK and p38 signaling pathways (Jiang and Guan, 2009). This evidence concerns the gene TGFB1 and pemphigus foliaceus.