Although we could not exclude the involvement of other 5-HT receptor subtypes (see Filip et al., 2010, for review), several lines of evidence suggested that 5-HT2A and 5-HT2C receptors again may be potential targets to treat some aspects of cocaine abuse (Higgins et al., 2013; Howell and Cunningham, 2015). Here, HTR2A is linked to cocaine abuse.