Conversely, combining anti-PD1/PDL1 with TKI therapy had a manageable safety profile and encouraging antitumor activity in other cancers, such as avelumab plus axitinib for advanced renal cell carcinoma and regorafenib plus nivolumab for advanced gastric or colorectal cancer (Motzer et al., 2019; Fukuoka et al., 2020). Here, PDCD1 is linked to hereditary clear cell renal cell carcinoma.