In Nlrp3-R258W mutant mice, more severe renal pathological changes occurred when intraperitoneal injection with pristane and specific abrogation of Nlrp3-R258W expression in myeloid cells conferred a therapeutic benefit to lupus Nlrp3-R258W mutant (Lu et al., 2017). This evidence concerns the gene NLRP3 and systemic lupus erythematosus.