These may influence the inflammatory response: IL-2 amplifies Treg cells that are linked to chemokines, CCL1 and CCL20, which suppress astrocytosis, contributing to repair (Ito et al., 2019); in animals with traumatic brain injury, IL-13 impacts microglia by converting M1/M2 microglia into anti-inflammatory M2 phenotype (Miao et al., 2020); IL-13 is found in resilient AD patients that have reduced glial activation, increased neuronal survival, and preserved cognition (Barroeta-Espar et al., 2019). This evidence concerns the gene CCL1 and Alzheimer disease.