The results revealed that hypertension markedly increased neuronal apoptosis in the cortex (13.71 ± 2.49% vs. 44.42 ± 3.86%, p < 0.01) and hippocampus (6.42 ± 2.50% vs. 27.57 ± 4.35%, p < 0.01, DG; 10.57 ± 1.9% vs. 24.28 ± 2.81%, p < 0.01, CA1; 6.57 ± 2.63% vs. 27.57 ± 2.63%, p < 0.01, CA3) of the mice in the angiotensin II infusion group compared with the mice in vehicle control. Here, AGT is linked to hypertensive disorder.