In addition to Aβ deposition, we observed that hypertension also induces neuronal death by neuro-inflammation, which is in line with previous evidence that proved ANG II-dependent microglial activation induces neuroinflammation acts via cross-talk between central renin-angiotensin system type 1 receptors (AT1R) and toll-like receptor 4 (TLR4) (Biancardi et al., 2016; Liu et al., 2016). This evidence concerns the gene TLR4 and hypertensive disorder.