We preliminarily examined the relationship between PM and Fazekas scores with potential confounding factors in each group, including demographic variables (i.e., age, education, and sex), vascular risk factors (e.g., hypertension, diabetes mellitus, hyperlipidemia, and coronary artery disease), and medication (e.g., antiplatelet, anticoagulant, antihypertensives, statins, oral antidiabetic drug, insulin, acetylcholinesterase inhibitors, memantine, hypnotics, antidepressants, and antipsychotics), using Pearson or point-biserial correlation coefficients, where appropriate. The gene discussed is INS; the disease is Hypertension.