A recent study confirmed that capillaries were constricted in proximity to Aβ plaques in human biopsy brain tissue and that mechanistically, reactive oxygen species in response to oligomeric Aβ mediated EDN1-induced pericyte contraction and consequent narrowing of capillaries in brain cortical slices, and was likely to contribute to cerebral hypoperfusion in AD (Nortley et al., 2019). Here, EDN1 is linked to Alzheimer disease.