Inhibitors of SGLT2 reduced the accumulation of Aβ in the cortical region of AD-T2DM mice (APP/PS1xdb/db mice) which is a genetically diabetic model of T2DM and showed the same effect on the amount of tau induced pathological cerebral atrophy (Wiciński et al., 2020). This evidence concerns the gene SLC5A2 and Cerebral atrophy.