Moreover, the effect of SGLT2is treatment on cerebral BDNF, since BDNF, a key protein promoting memory and survival of neurons, is significantly reduced in diabetic patients, and diabetic animals including db/db mice and the decrease in cerebral BDNF is shown to be associated with cognitive decline (Lin et al., 2014; Table 2 for a summary, illustrated in Figure 3). This evidence concerns the gene BDNF and Mental deterioration.