Inhibitors of SGLT2 reduced the accumulation of Aβ in the cortical region of AD-T2DM mice (APP/PS1xdb/db mice) which is a genetically diabetic model of T2DM and showed the same effect on the amount of tau induced pathological cerebral atrophy (Wiciński et al., 2020). The gene discussed is APP; the disease is Cerebral atrophy.