CDKN2A and non-small cell lung carcinoma: The interaction of the MIR31HG transcript with the genomic regions of INK4A and MIR31HG contributes to the recruitment of polycomb-group protein complexes and then the repression of INK4A. In addition, SP1-induced MIR31HG was found to be significantly upregulated in NSCLC tissues and cell lines, which promotes cell migration and invasion by sponging miR-214 [79].