NPC2 and glioblastoma: Neftel and co-workers generated and analyzed single-cell RNA-seq data from 28 pediatric and adult glioblastoma tumors to identify four major neoplastic cell-types defined by six gene modules; (1) Mesenchymal—Hypoxia independent (MES1like) and hypoxia dependent (MES2like) mesenchymal related gene sets, (2) Astrocytic—astrocytic (AC-like) marker gene set, (3) Oligo-oligodendroglial (OPC-like) lineage marker gene set, and (4) Neural-stem and progenitor cell signatures (NPC1-like and NPC2-like), as well as two cell cycling modules (G1S and G2M—CC) (Supplementary File 3).