Single-cell transcriptome analysis of isocitrate dehydrogenase wildtype (IDHwt) glioblastoma and IDH-mutant astrocytomas revealed different patient-independent glioma cell-types, i.e., OPC-like, NPC-like, Mes-like, AC-like, and cell cycling stem cell-like8,54. The gene discussed is IDH3A; the disease is glioblastoma.