Dkk3 was increased by 7–13 fold at week 1 (p < 0.05 in both WT and KO vs. sham) which is similar to its increase in myocardial tissues (6–11 fold), while Dkk1 was not statistically affected (p > 0.09) after MI. The gene discussed is DKK1; the disease is myocardial infarction.