TFE3 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: Our findings provided important new insights into key genomic and biologic features underlying TFE3-tRCC development and progression, confirmed the promotion role of copy number alterations in tumor progression, revealed the prognostic value of TFE3 fusion patterns, and described five distinct molecular clusters associated with different transcriptional signatures.