TFE3 and renal cell carcinoma: Using a refined RCC immune cell gene-specific signatures18, we found that compared with TCGA RCC subtypes, the T helper 2 cell (Th2) signature was increased in TFE3-tRCC, while the activated dendritic cell (aDC) and plasmacytoid dendritic cell (pDC) signatures had decreased expression (Fig. 4E and Supplementary Figure 8B).