Radiologically, cases with ASPSCR1-TFE3 fusion presented with features typical of hypervascularity and calcification on CT scan, while MED15-TFE3 fusion tRCC often presented as cystic masses (Supplementary Figure 3B). Here, MED15 is linked to renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.