Gene set enrichment analysis (GSEA) demonstrated enrichment of transcriptional pathways involved in proliferation (E2F targets and G2M checkpoint), PI3K/ATK/mTOR, and p53 signaling in TFE3-tRCC (Fig. 4C). This evidence concerns the gene BTK and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.