We found that tumors with 22q loss were correlated with ASPSCR1-TFE3 fusion (4/4 vs. 2/38, P = 0.005), higher ISUP nuclear grade (ISUP ≥ 3, 7/19 vs. 0/27, P = 0.004) and more frequent lymph node metastasis (5/7 vs. 2/39, P = 0.004). The gene discussed is TFE3; the disease is metastatic malignant neoplasm in the lymph nodes.