We find that the 214 entropy elevated and average-methylation stable genes (Q1, Supplementary Fig. 11b) are not significantly repressed in the tumor uterus sample compared to the matched normal sample (Supplementary Fig. 11d, p value = 0.2), and that the single known TSG (MLF1, Supplementary Fig. 11e) in the Q1 group can also be detected by methylation concurrence (Fig. 3d). The gene discussed is MLF1; the disease is neoplasm.