PTPRC and neoplasm: To decipher the cell composition within the ESCC tumors, we performed scRNA-seq and T cell receptor (TCR)-seq (for CD45+ cells only) on 60 ESCC tumor and 4 adjacent normal tissue samples obtained from 60 individuals using 10X Genomics platform (Fig. 1a; Supplementary Fig. 1a; Supplementary Data 1a and 2).