Thirdly, we have identified several different cellular interactions in the TME, such as the interaction between TFH1 and GC B cells, which produces an antitumor immune environment by the formation of TLS, the interaction between TEC2 and TN cells, which impedes infiltration of immune cells to tumor tissues, and the interaction between TH17 cells and CAF2 mediated by cytokines secreted from TH17 cells, which enhances CAF2 cell activity. The gene discussed is CNOT8; the disease is neoplasm.