Average number (per mice) of intestinal polyps that were adenomatous with high-grade and low-grade dysplasia are higher (0.76 and 0.33 respectively) compared to the similar pathology observed in Apc+/− (0.15 and 0.1 respectively) or Pms2ki/+; Apc+/− (0.05 and 0.1 respectively) (Fig. 3C and Supplementary Table 2). This evidence concerns the gene APC and intestinal polyp.