EGFR and lung adenocarcinoma: Osimertinb and atezolizumab had stronger cytotoxic synergism compared to osimertinib and nivolumab in both osimertinib-sensitive, EGFR-mutant (11 ± 6% vs 25 ± 6%, P < 0.05) (Fig. 8a) and osimertinib-resistant, EGFR-mutant lung adenocarcinomas (8 ± 1% vs 28 ± 3%, P < 0.05) (Fig. 8b).