Multivariate analysis using the Cox proportional hazards regression model revealed that ALCs, CD4 plus CD8 counts, PD-L1 IHC and TMB are an independent significant predictor for PFS (P = 0.038, P = 0.021, P = 0.003 and P = 0.004, respectively), and CD4 plus CD8 counts remained a significant predictor for OS (P = 0.008, HR 5.96, 95% CI 1.60–22.2), for NSCLC patients without driver oncogenes receiving ICI treatment (Tables 6 and 7). This evidence concerns the gene CD8A and non-small cell lung carcinoma.