EPHX2 and Alzheimer disease: As some ethanolamides, like PEA, were reported to be associated with cognition in AD patients in an analysis of a small (n = 40) cohort [38] and sEH reports are based mainly on animal models and brain sEH gene expression [39], our study provides the first comprehensive analysis of AD-associated alteration in the levels of the array of these lipid mediators in plasma and CSF.