TP53 and breast carcinoma: In addition, Isobe et al. showed that the members of the manumycin family of polyketides (Fig. 17c) are covalently linked to the cysteine ​​residue (C374) in RING E3 ligase UBR7 and bind to the neosubstrate tumor-suppressor TP53 in breast cancer cells, thereby acting as a molecular glue to increase p53 transcriptional activation and induce cell death [136].