This strategy is in line with a recent study demonstrating that inhibiting Tubulin beta-4A chain (TUBB4) reduces levels of GLUT1, found to be overexpressed in astrocytoma, and inhibits self-renewal and tumor-initiating capacity in GSCs, although TUBB4 inhibition might well negatively impact on important cellular functions as well [49]. This evidence concerns the gene TUBB4A and astrocytoma (excluding glioblastoma).