TF and Hepatosplenomegaly: Furthermore, the liver and spleen of mice were weighted, and we noticed that the mice in the negative control, PLGA NPs, and Tf-Cou6-PLGA NPs groups developed more severe hepatosplenomegaly compared with the Ab@Tf-Cou6-PLGA NPs group (Fig. 6c, d and Additional file 6: Fig. S6a).