DDIT3 and head and neck squamous cell carcinoma: Similarly, Senkal et al. found that C16 ceramide produced by LASS6 is a survival factor that protects head and neck squamous cell carcinoma cells from apoptosis induced by endoplasmic reticulum stress by selectively regulating the ATF6 / CHOP axis and inducing the growth of xenografted tumors in mice [39].