INS and obesity due to melanocortin 4 receptor deficiency: Female subjects had lower markers of obesity (i.e., BMI, waist-to-hip ratio), glucose homeostasis (i.e., fasting glucose, fasting insulin, HbA1c), blood pressure, albuminuria, interleukin﻿-6, and liver enzymes compared to male participants (all p < 0.05; Table 1).