Of the 37 patients with ≥ twofold increase in TNFRSF21 expression, 20 (54.1%) had local tumor recurrence, while 26 of 32 (81.3%) patients with < twofold increase in TNFRSF21 expression developed local recurrence within 24 months after dCRT, and the median LRFS in the two groups was 21.0 and 9.0 months, respectively (P = 0.001; Fig. 6K). This evidence concerns the gene TNFRSF21 and neoplasm.