The profiling data showed that 7 apoptosis-related genes were concordantly > twofold downregulated in recurrent tumor samples compared with the expression in paired primary tumor samples, including AKT1, BAG4, BCL2A1, BFAR, CARD6, CASP8 and TNFRSF21 (Fig. 1). The gene discussed is CARD6; the disease is neoplasm.