We investigated the correlations between MARCH3 expression and the immune marker sets of TICCs including CD8 + T cells, T cells (general), B cells, monocytes, TAMs, M1 and M2 macrophages, neutrophils, NK cells and DCs, and the different functional T cells included Th1 cells, Th2 cells, Tfh cells, Th17 cells, Tregs and exhausted T cells in HCC. This evidence concerns the gene MARCHF3 and hepatocellular carcinoma.