Comparing with group A, 556 mRNAs, 120 circRNAs, 87 lncRNAs, and 96 miRNAs were differentially expressed in group B. Finally, we identified top 8 of mRNAs, circRNAs and lncRNAs that associate HCC patients who IFN-α therapy as showed in heat map (Fig. 1a, b, c). Here, IFNA1 is linked to hepatocellular carcinoma.