In this study, low levels of T lymphocytes (p < 0.001), NK cells (p < 0.001), CD8+ T cells (p = 0.008), naïve CD4+/CD4+ (p < 0.001), and naïve CD4+ T cells (p < 0.001) was observed in lung cancer patients compared to controls. The gene discussed is CD8A; the disease is lung cancer.