The classical mechanism of cough hypersensitivity involves the inflammatory-mediator activation of TRPV1, which stimulates the vagal afferent terminals, resulting in neurogenic airway inflammation, leading to the release of neuropeptides such as SP and CGRP which stimulates local nerves as well as transmitting signals to the central nervous system, thereby increasing cough sensitivity [42]. Here, TRPV1 is linked to inflammation.