The RRs for neutropenia, anemia, pneumonia, diarrhea, and fatigue in the MAbs targeting CD38 group vs PD-1/PD-L1 group by indirect comparison were 1.207 (95%CI 0.94–1.55), 0.566 (95%CI 0.332–0.963), 1.325 (95%CI 0.725–2.419), 0.446 (95%CI 0.102–1.956), and 5.00 (95%CI 1.717–14.56), respectively. Here, CD274 is linked to Decreased total neutrophil count.