Among 144 cases of ESCC tissue, 104 (72%) showed positive expression of UBE2C protein (with a specified score of more than 6 being positive, and a score of less than or equal to 6 being negative), whereas only 47 (33%) of 142 adjacent tissues showed positive expression of UBE2C (p < 0.001) (Fig. 4a-d). This evidence concerns the gene UBE2C and esophageal squamous cell carcinoma.