We conducted a comprehensive evaluation of the UBE2C expression in ESCC by collecting the protein and mRNA expression data (including in-house RNA- seq, in-house IHC, TCGA-GTEx RNA-seq and tissue microarray), including 772 ESCC samples and 1837 control samples, to calculate a combined SMD and sROC. Here, UBE2C is linked to esophageal squamous cell carcinoma.