Ko et al. [32] extracted the TCR from the serum of patients with SJS/TEN taking CBZ and found that in the patients positive for HLA-B*1502, the TCR clonal type VB-11-ISGSY was present, while in the CBZ-tolerant group, this clonal type was not found, indicating that the VB-11-ISGSY clonal type is related to the induction of SJS/TEN. This evidence concerns the gene HLA-B and toxic epidermal necrolysis.