At present, researchers believe that HLA-A*3101 is strongly correlated with AED-MPE [20, 25] and that HLA-A*3101 positivity is associated with MPE and DRESS induced by CBZ [26], while HLA-B*1502 positivity is more significant associated with CBZ induced SJS /TEN. This evidence concerns the gene HLA-A and toxic epidermal necrolysis.