CaCCs encoded by ANO1 have been implicated in many diseases such as systemic [222–225] and pulmonary hypertension [42,221,226–230], asthma [207,209,231], defective epithelial ion transport in the lungs and gut [207,232–239], and many forms of cancer [123,240–246] to name a few. This evidence concerns the gene ANO1 and pulmonary arterial hypertension.