Pyroptosis-related genes (PRGs), such as NLRP3 [29,30], Caspase 1 (CASP1) [31], Gasdermin D (GSDMD) [11,27] and Gasdermin E (GSDME) [32], are strongly implicated in oncogenesis and tumor progression. The gene discussed is GSDME; the disease is neoplasm.