NLRP3 and non-small cell lung carcinoma: In addition, there exist interplay between cell apoptosis and pyroptosis [36,37], and our data showed that blockage of pyroptotic cell death by NLRP3 ablation or pyroptosis inhibitor NSA abrogated the promoting effects of miR-556-5p downregulation on cell apoptosis in cisplatin treated CR-NSCLC cells, which were partially supported by the previous work [36,37], indicating that targeting miR-556-5p aggravated cieplatin-induced CR-NSCLC cell apoptosis via activating NLRP3-mediated cell pyroptosis.