NLRP3 and non-small cell lung carcinoma: According to the existed information that NLRP3-mediated pyroptotic cell death is critical for modulating cisplatin-resistance [33–35], we validated that long-term low-dose cisplatin exposure downregulated NLRP3 expressions in CR-NSCLC cells, indicating that NLRP3-mediated pyroptotic cell death was inactivated in CR-NSCLC cells compared to the corresponding CS-NSCLC cells.