Riggio et al. [56] demonstrated that AKT1 promoted cell proliferation via upregulating cyclin-dependent kinase 1 and S6, and C-X-C motif chemokine receptor 2 (CXCR2) promoted breast cancer metastasis and chemoresistance by inhibiting AKT1 and activating COX2 (Cyclooxygenase 2). This evidence concerns the gene PTGS2 and breast carcinoma.