Intriguingly, knockdown of XR_001779380 in IEC4.1 cells resulted in significant suppression of IFN-γ-mediated epithelial defense, reflected by a higher infection burden in XR_001779380 siRNA-treated and IFN-γ-primed cells compared than that in IFN-γ-primed cells treated with the nonspecific siRNA controls (Fig. 2B). The gene discussed is IFNG; the disease is infection.