We infected these mice with a recombinant version of JHMV (rJHMV) and found that infection of CX3CR1-DP1−/− mice (microglia-specific DP1 ablation) resulted in a dysregulated immune response and increased mortality, effectively phenocopying rJHMV-infected mice with global depletion of DP1 expression. The gene discussed is PTGDR; the disease is infection.