CD8A and non-small cell lung carcinoma: In EGFR-Ex20mut samples, we observed significant up-regulation of IFNA and CSF1R. Recent data demonstrated that upon T-cell receptor recognition, specific NSCLC tumor cells strongly induced the expression of TNFSF10, an apoptosis-inducing cytokine, on CD4+ but not on CD8+ cytotoxic T-cell clones.