It is also likely that the interpretation of tau PET signal in clinical trials of AD will be more complex than amyloid PET, given the focal nature of tau PET signal (Schwarz et al., 2016) along with greater sources of off-target binding in tau PET ligands (Leuzy et al., 2019; Lemoine et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.