Some studies have shown a positive relation in baseline and future tau accumulation in IT amongst CU (Hanseeuw et al., 2019; Knopman et al., 2020) and in a composite cortical region across the AD continuum (Pontecorvo et al., 2019), whereas others have shown that baseline tau is a non-significant predictor of longitudinal change in a temporal region across the AD continuum (Jack et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.