Thus, Che et al,69 considering the hypothesis that functional polymorphisms in the insulin receptor (INSR) gene, the insulin receptor substrate 1 (IRS1) gene, and the insulin receptor substrate 2 (IRS2) gene could be associated with the response to ASM in patients with epilepsy, evaluated 376 patients with TLE—201 refractory and 175 responsive. The gene discussed is IRS2; the disease is epilepsy.