The use of Pirc rat (F344/NTac‐Apcam1137), a genetic model of Apc‐driven CRC developing preneoplastic lesions such as mucine depleted foci (MDF) and adenomas in the colon, allows the study of tumorigenesis during its evolution from the absence of lesions, to the development of MDFs and then macroscopic adenomas.18, 19. This evidence concerns the gene APC and adenoma.