A proteomic analysis was performed on colon fibroblasts isolated from apparent normal mucosa of FAP patients (APC+/−) or from sporadic colon cancer: interestingly, changes observed in those fibroblasts were shared by epithelial cells isolated from colonic crypts in the same subgroups of patients, and an enhanced oxidative stress response was found in both fibroblasts and epithelial cells mutated in APC.15, 16. Here, APC is linked to malignant colon neoplasm.