The pathophysiological features of human aortic aneurysm can be induced in animal models by elastase, calcium chloride, angiotensin II or transgenesis, which partially enable investigation of the etiology, pathogenesis, and therapeutic targets of TAA at an early stage (Eckhouse et al., 2013; Ikonomidis et al., 2003; Mao et al., 2015). Here, AGT is linked to aortic aneurysm.