We found ACTB positively correlated with metastasis (ρ = 0.62, P = 0), invasion (ρ = 0.51, P = 0), hypoxia (ρ = 0.43, P = 0.004), epithelial–mesenchymal transition (EMT) (ρ = 0.40, P = 0) and negatively correlated with stemness (ρ = -0.37, P = 0) in HNSCC (Figure 7(b)). The gene discussed is ACTB; the disease is head and neck squamous cell carcinoma.