PIK3CA and neoplasm: Nepal et al. analyzed 92 GBC whole-exome sequencing tumor/normal pairs; they annotated 3,845 single nucleotide variants and 432 small insertion/deletions, including TP53, ELF3, ERBB2, CDC27, TGFBR2, PIK3CA, KIR2DL4, KIR2DL3, and ARID2 [26].